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Delta Sleep-Inducing Peptide · Neuropeptide Research

DSIP Research Compound

Delta Sleep-Inducing Peptide — a 9-amino acid neuropeptide first characterized from rabbit thalamic perfusate. Supplied as lyophilized powder in 5mg research vials. HPLC and mass spectrometry verified by Krause Analytical. For research use only.

5mg Vial COA — Krause Analytical Sabrina Runbeck, PA-C Finnrick Pulse Research Use Only
Inquire About DSIP Full Catalog
Compound Data
Compound DSIP
CAS Number 62568-57-4
Formula C₃₅H₄₈N₁₀O₁₅
Mol. Weight ~848 Da
Residues 9-AA Nonapeptide
Origin Thalamic (rabbit)
Supply Size 5mg / vial
Purity (HPLC) ≥99%
Testing HPLC + MS

Compound Overview

What Is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide — a peptide consisting of nine amino acid residues — classified within the neuropeptide research category. It was first characterized in 1977 by Monnier and colleagues at the University of Basel, who isolated it from the venous blood of rabbits following thalamic stimulation. The original research described it as originating from a thalamic perfusate.

The primary structure of DSIP consists of the following amino acid sequence in single-letter and three-letter notation:

Amino Acid Sequence (N→C)
Trp Ala Gly Gly Asp Ala Ser Gly Glu

DSIP is classified as a neuropeptide in preclinical research literature. Published research has examined its interaction with neuroregulatory pathways in animal model contexts. As a research compound, it is supplied as lyophilized powder, requiring reconstitution prior to use in laboratory settings.

For research use only. Not for human use.

Technical Data
Full Name Delta Sleep-Inducing Peptide
Abbreviation DSIP
CAS Number 62568-57-4
Molecular Formula C₃₅H₄₈N₁₀O₁₅
Molecular Weight ~848 Da
Residue Count 9 amino acids (nonapeptide)
Origin Source Rabbit thalamus perfusate
Discovery Year 1977 (Monnier et al.)
Classification Neuropeptide
Sequence Labs SKU 5mg lyophilized vial
Storage (lyophilized) −20°C, protected from light
Post-reconstitution 2–8°C, research use only

Preclinical Literature

Research Background

Published research has examined DSIP across multiple preclinical and laboratory contexts since its initial characterization in 1977. The following areas represent the primary domains covered in peer-reviewed literature.

Sleep Architecture Research in Animal Models

Published research has examined DSIP in the context of sleep architecture studies using rodent and rabbit animal models. Laboratory investigations have explored how this neuropeptide interacts with neuroregulatory circuitry associated with sleep-wake states in preclinical research settings.

Hypothalamic-Pituitary Axis Research

Preclinical research has examined interactions between DSIP and the hypothalamic-pituitary axis. Published research has explored neuropeptide signaling pathways within this neuroendocrine axis in laboratory and animal model contexts.

Neuropeptide Receptor Binding Research

In vitro research has examined DSIP receptor binding characteristics. Published research has explored its interaction with neuropeptide receptor systems at the molecular and cellular level, contributing to a broader understanding of neuropeptide pharmacology in preclinical models.

Stress Peptide Pathway Research in Preclinical Models

Published research has examined DSIP within the context of stress-related neuropeptide pathways in preclinical animal models. Laboratory investigations have explored the relationship between DSIP and neuroregulatory mechanisms in stress pathway research settings.

Circadian Rhythm Neuroscience Research

Published research has examined DSIP in circadian rhythm neuroscience research contexts. Preclinical studies have investigated neuropeptide signaling within circadian regulatory systems, positioning DSIP as a compound of interest for researchers studying biological rhythm pathways.

Sequence Labs Supply

DSIP at Sequence Labs

Research-grade DSIP supplied as lyophilized powder in 5mg vials. Every batch independently verified by Krause Analytical using dual HPLC and mass spectrometry methodology.

Research Compound
DSIP — Delta Sleep-Inducing Peptide
~$45
5mg lyophilized vial · CAS 62568-57-4
  • 5mg lyophilized powder, single-use research vial
  • HPLC + mass spectrometry purity verification (≥99%)
  • Certificate of Analysis issued by Krause Analytical, independent laboratory
  • Molecular formula verified: C₃₅H₄₈N₁₀O₁₅, MW ~848 Da
  • Stored under controlled conditions prior to shipment
  • For in vitro and preclinical research use only
Reviewed By
Sabrina Runbeck, PA-C
Licensed Physician Assistant — Catalog Review
Finnrick Pulse
Research Quality Verification
Quality Standards
Third-Party Verified
  • Krause Analytical — independent third-party laboratory responsible for HPLC and mass spectrometry analysis on every DSIP batch
  • HPLC purity ≥99% — high-performance liquid chromatography with documented retention time and peak integration
  • Mass spectrometry confirmation — molecular weight verification against expected MW ~848 Da
  • COA availability — Certificate of Analysis available for each batch, accessible on request via the COA Library
  • Lyophilized format — stable powder form for research sample storage and handling
For Research Use Only — Not for Human Use

Laboratory Reference

Reconstitution Reference

The following outlines general laboratory practice for preparing a lyophilized neuropeptide research sample for in vitro or preclinical research use. This information is provided for qualified research professionals only.

1
Prepare the solvent
Bacteriostatic water (0.9% benzyl alcohol) is the standard solvent used in laboratory settings for reconstituting lyophilized neuropeptide research samples. Ensure the solvent has been stored correctly and is within its verified use period.
2
Introduce solvent to the research sample
Using a sterile syringe and needle under appropriate laboratory conditions, introduce the bacteriostatic water solvent slowly along the inner wall of the vial containing the lyophilized DSIP research sample. The volume introduced will determine the concentration of the reconstituted solution.
3
Allow dissolution
Gently swirl — do not shake — the vial until the lyophilized powder has fully dissolved into solution. The reconstituted research sample should appear as a clear, colorless to faintly colored solution with no visible particulate matter.
4
Label and store
Label the reconstituted research sample with compound name, concentration, date of reconstitution, and researcher identification per laboratory protocol. Store at 2–8°C when not in active use. Use within the timeframe specified in your laboratory's standard operating procedure.

Questions & Answers

Frequently Asked Questions

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide — a peptide composed of nine amino acid residues — classified as a neuropeptide in preclinical research literature. Its sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, with molecular formula C₃₅H₄₈N₁₀O₁₅ and a molecular weight of approximately 848 Da (CAS 62568-57-4). Sequence Labs supplies DSIP as a lyophilized research compound in 5mg vials. For research use only.
DSIP was first characterized in 1977 by Monnier and colleagues at the University of Basel. The research team isolated the peptide from the venous blood of rabbits following electrical stimulation of the thalamic region — specifically from what researchers described as rabbit thalamus perfusate. The original published research proposed this nonapeptide as a thalamic-origin neuropeptide involved in neuroregulatory signaling, establishing the foundation for subsequent preclinical and in vitro research.
Published research has examined DSIP across several preclinical domains: (1) sleep architecture research in animal models, (2) hypothalamic-pituitary axis research, (3) neuropeptide receptor binding research, (4) stress peptide pathway research in preclinical models, and (5) circadian rhythm neuroscience research. All research contexts involve preclinical animal models or in vitro laboratory settings. For peer-reviewed literature, search "DSIP delta sleep inducing peptide" in PubMed (pubmed.ncbi.nlm.nih.gov).
Sequence Labs supplies DSIP in 5mg research vials, priced at approximately $45 per vial. Each vial contains lyophilized DSIP powder (CAS 62568-57-4) at ≥99% purity, verified by Krause Analytical using HPLC and mass spectrometry. A Certificate of Analysis is available for every batch via the COA Library.
For laboratory research purposes, researchers typically introduce bacteriostatic water as the solvent into the lyophilized DSIP vial. Using a sterile syringe, the solvent is slowly introduced along the inner wall of the vial and the vial is gently swirled — not shaken — until fully dissolved. The reconstituted research sample should be labeled with date, compound, and concentration, then stored at 2–8°C when not in active use. This procedure is provided as a laboratory reference for qualified research professionals only. For research use only. Not for human use.
No. All Sequence Labs products, including DSIP, are supplied exclusively for in vitro and preclinical research use by qualified research professionals. They are not intended for human use, human consumption, self-experimentation, or any therapeutic application. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. For research use only.