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Pineal Tetrapeptide · Telomerase Research

Epithalon
Research Compound

A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, the natural pineal gland extract. Supplied as a 10mg lyophilized research vial, HPLC + MS verified by Krause Analytical. For research use only — not for human use.

10mg Research Vial COA — Krause Analytical Finnrick Pulse Verified Reviewed: Sabrina Runbeck, PA-C For Research Use Only
Compound Data
CAS 307297-39-8
Formula C₁₄H₂₂N₄O₉
MW ~390 Da
Type Tetrapeptide
Sequence Ala-Glu-Asp-Gly
Origin Pineal (synthetic)
SL Size 10mg
Purity ≥99% (HPLC+MS)

Compound Overview

What Is Epithalon?

Epithalon (also written Epitalon) is a synthetic tetrapeptide composed of four amino acid residues in the sequence Alanine-Glutamic acid-Aspartic acid-Glycine — abbreviated Ala-Glu-Asp-Gly. It carries the molecular formula C₁₄H₂₂N₄O₉ with a molecular weight of approximately 390 Da and is catalogued under CAS number 307297-39-8.

The peptide was developed as a synthetic analog of epithalamin, a polypeptide fraction originally isolated from bovine pineal gland tissue. The isolation and characterization of epithalamin, and the subsequent synthesis of Epithalon as a defined four-amino-acid unit, were performed at the St. Petersburg Institute of Bioregulation and Gerontology.

Within the peptide research classification system, Epithalon belongs to the category of pineal peptide bioregulators — short-chain peptides whose research interest centers on their interaction with pineal gland-associated signaling pathways. Published research has investigated it primarily in cell culture and preclinical animal model contexts. It is classified as a research compound and is not approved for human use.

Amino Acid Sequence
Ala · Glu · Asp · Gly
Khavinson Research History

Prof. Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology (Russia) have published extensively on pineal-derived peptide bioregulators beginning in the 1970s. Their body of work introduced the concept of short peptide bioregulation — the hypothesis that di- and tetrapeptide sequences derived from tissue extracts could influence cell-type-specific gene expression in preclinical models.


Epithalon emerged from this research program as the synthetic equivalent of the active fraction of epithalamin. Published research from this group and independent laboratories has since examined Epithalon in cell cycle, telomerase pathway, circadian rhythm, and oxidative stress contexts using in vitro and animal models. All research classification applies: findings do not establish conclusions regarding human biology.

Research Classification: Epithalon is a research sample for in vitro and preclinical study only. It is not a pharmaceutical, not a dietary supplement, and is not intended for human or veterinary use. For research use only.

Published Research Areas

Research Background

The following five research areas represent domains in which published preclinical literature has examined Epithalon. All work cited applies to in vitro and animal model contexts. No conclusions regarding human physiology are intended or implied.

Telomerase Activation Research in Cell Models

Published research has examined Epithalon's effect on telomerase enzyme activity in somatic cell culture models. Preclinical research has investigated whether Epithalon influences the expression of telomerase reverse transcriptase (TERT) in proliferating human cell lines. Findings are from in vitro studies only.

In Vitro · Cell Lines
Pineal Peptide Bioregulation Research

As a synthetic analog of the natural pineal extract epithalamin, Epithalon is a primary subject of pineal peptide bioregulation research. Published research has examined its interaction with gene expression profiles in cell models, representing part of a broader body of work on short-chain peptide bioregulators originating from pineal tissue research.

Bioregulation · Pineal Research
Circadian Rhythm Research in Preclinical Models

Given its pineal gland research origins, published preclinical research has investigated Epithalon in animal models examining circadian rhythm-associated endpoints. Research has explored its relationship to melatonin pathway markers in rodent models. These findings are preclinical and cannot be extrapolated to human circadian biology.

Animal Models · Circadian
Cell Cycle and Proliferation Research In Vitro

Preclinical research has investigated Epithalon's influence on cell cycle progression and proliferation markers in cell culture systems. Published research has examined its effects on cell division parameters and proliferative indices across various cell line types. All findings originate from in vitro experimental settings.

In Vitro · Cell Cycle
Oxidative Stress Pathway Research in Animal Models

Published research has examined Epithalon in preclinical animal models assessing markers associated with oxidative stress pathways, including antioxidant enzyme activity and lipid peroxidation indices. These are animal model findings and do not constitute evidence of equivalent effects in human biology.

Animal Models · Oxidative Stress

Search the primary literature on PubMed — published research indexed under "epithalon," "epitalon," and "telomerase" keywords.

Search PubMed →

Sequence Labs Supply

Epithalon at Sequence Labs

SL-EPITH-10
Epithalon (Epitalon)
~$55 / 10mg vial
  • Size: 10mg lyophilized research vial
  • Purity: ≥99% verified by HPLC and mass spectrometry
  • Testing Lab: Krause Analytical — independent third-party
  • COA Platform: Finnrick Pulse — batch-traceable certificate of analysis
  • Catalog Review: Sabrina Runbeck, PA-C — licensed physician assistant review of catalog integrity
  • Form: Lyophilized powder, sealed vial
  • Storage: −20°C recommended for long-term research storage
View on Products Page
HPLC Verified Mass Spec Confirmed Krause Analytical Finnrick Pulse COA Sabrina Runbeck PA-C ≥99% Purity Research Use Only
Why Dual Verification Matters

HPLC (high-performance liquid chromatography) confirms purity percentage. Mass spectrometry independently confirms molecular identity by exact mass. Together, these two methods establish both that the sample is pure and that it is the compound it claims to be.

Sequence Labs tests every batch through Krause Analytical, an independent third-party laboratory. COAs are traceable via Finnrick Pulse and accessible on request. Catalog integrity is reviewed by Sabrina Runbeck, PA-C.

View COA Library

Laboratory Reference

Reconstitution Reference

The following is provided as general laboratory reference for researchers working with lyophilized peptide research samples. All handling should conform to applicable laboratory safety protocols. For research use only — not for human use.

01
Prepare Solvent

Bacteriostatic water (0.9% benzyl alcohol) is standard for lyophilized peptide research samples. Sterile water for injection may also be appropriate depending on intended research application. Allow solvent to reach ambient temperature before use.

02
Introduce Solvent to Vial

Using appropriate sterile technique, introduce solvent slowly along the inner wall of the vial — directing the solvent stream at the glass, not directly at the lyophilized cake. Standard research practice for a 10mg research sample is to introduce 1–2mL solvent volume, yielding a 5–10mg/mL research solution.

03
Allow Dissolution

Allow the lyophilized material to dissolve without mechanical agitation. Gentle swirling may assist dissolution. Do not vortex or shake. Epithalon is water-soluble and typically dissolves completely within a few minutes at ambient temperature.

04
Storage of Reconstituted Sample

Store the reconstituted research solution at 2–8°C (refrigerated). Protect from light. Use within 28 days for in vitro research purposes, or as appropriate per the specific research protocol. Lyophilized (unreconstituted) research samples should be stored at −20°C.

Research Use Only. This reconstitution reference is provided for informational purposes for qualified researchers conducting in vitro and preclinical studies with Epithalon research samples. This information does not constitute medical advice, pharmacological guidance, or instructions for human use. Epithalon supplied by Sequence Labs is not intended for human use, human consumption, or veterinary use. Not for human use.

FAQ

Frequently Asked Questions

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly. It was developed as a synthetic analog of epithalamin, a natural peptide fraction originally extracted from bovine pineal gland tissue, by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Molecular formula: C₁₄H₂₂N₄O₉, MW approximately 390 Da, CAS 307297-39-8. Sequence Labs supplies Epithalon as a 10mg lyophilized research vial for in vitro and preclinical research use only.
Published research has examined Epithalon's interaction with telomerase activity in cell culture models. Preclinical research has investigated whether the Ala-Glu-Asp-Gly sequence influences the expression of telomerase reverse transcriptase (TERT) in somatic cell lines in vitro. These are in vitro findings. No conclusions regarding telomere biology or cellular aging in human subjects should be drawn from preclinical cell model data.
Epithalon was developed by Prof. Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology (Russia). Research originating from this institute over several decades developed the broader concept of peptide bioregulation — the study of short-chain peptides derived from tissue extracts and their influence on cell biology in preclinical models. Epithalon is among the most extensively published compounds from this research program.
Sequence Labs carries Epithalon as a 10mg lyophilized research vial (~$55). Each batch is independently tested by Krause Analytical using both HPLC and mass spectrometry to verify purity (≥99%) and molecular identity. Certificates of analysis are batch-traceable via the Finnrick Pulse platform. Catalog integrity is reviewed by Sabrina Runbeck, PA-C.
For laboratory research purposes, the lyophilized Epithalon research sample is reconstituted by introducing bacteriostatic water or sterile water as solvent into the vial. Standard practice is to introduce solvent slowly along the inner vial wall, allow dissolution without agitation, and store the reconstituted research solution refrigerated (2–8°C). Specific volumes should be determined by the researcher's protocol requirements. All handling should follow applicable biosafety procedures. For research use only — not for human use.
No. Epithalon supplied by Sequence Labs is strictly for in vitro research and preclinical study purposes only. It is not intended for human use, human consumption, self-experimentation, or veterinary use. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Researchers must comply with all applicable local, state, and federal regulations governing research compound procurement and use.

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