For research use only. Not for human use. All Sequence Labs compounds are supplied strictly for in vitro and preclinical research by qualified investigators. No information on this page constitutes medical advice or product claims for human application.
Compound Profile
What Is Selank?
Selank is a synthetic heptapeptide research compound with the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was developed at the Institute of Molecular Genetics, Russian Academy of Sciences, as a structural and functional analog of tuftsin — a naturally occurring immunomodulatory tetrapeptide (Thr-Lys-Pro-Arg) found endogenously as a fragment of the IgG heavy chain.
The Pro-Gly-Pro extension appended to the C-terminus of the base tuftsin sequence is a deliberate stability modification: published research has examined how this tripeptide tail significantly reduces enzymatic degradation of the molecule in preclinical model systems, increasing its half-life relative to native tuftsin while preserving the core structural motif relevant to tuftsin receptor mechanism research.
As a research compound, Selank has been investigated in preclinical model systems in the context of GABAergic neuropeptide signaling, tuftsin receptor mechanism pathways, enkephalin system research, and immune-modulation research — all areas where the parent tuftsin scaffold has established biological literature. Sequence Labs supplies Selank as lyophilized powder in 5mg and 10mg research vials, verified by HPLC and mass spectrometry.
Thr — Lys — Pro — Arg — Pro — Gly — Pro
Technical Specifications
- Compound Selank
-
Classification
Synthetic heptapeptide
Tuftsin analog - Molecular Formula C₃₃H₅₇N₁₁O₉
- Molecular Weight ~751 Da
- CAS Number 129954-34-3
-
Sequence
Thr-Lys-Pro-Arg-
Pro-Gly-Pro -
Origin
Institute of Molecular Genetics,
Russian Academy of Sciences - Research Form Lyophilized powder
- Sizes Available 5mg · 10mg
-
Testing
HPLC + MS
Krause Analytical
Published Research Areas
Research Background
Published research has examined Selank across multiple preclinical investigative contexts. The following areas represent the primary research literature associated with this compound. All research referenced is preclinical or in vitro in nature.
GABA-A Modulation Research in Preclinical Models
Published research has examined Selank's interaction with GABA-A receptor subunits in rodent models. Investigators have explored changes in GABAergic signaling parameters following exposure in preclinical model systems, positioning this compound within the neuropeptide–GABA pathway research area.
Tuftsin Receptor Mechanism Research
As a structural analog of the endogenous tetrapeptide tuftsin, published research has examined Selank's binding characteristics at tuftsin receptor sites. Researchers have investigated structural determinants of receptor engagement and the role of the Pro-Gly-Pro extension in modulating receptor affinity profiles.
Enkephalin System Research in Animal Models
Published research has examined Selank's relationship with enkephalin degradation pathways in animal models. Specific investigations have focused on enkephalinase activity modulation and downstream signaling in the context of neuropeptide receptor research in preclinical settings.
Neuropeptide Signaling Pathway Research
Selank has been studied as a model compound in neuropeptide signaling pathway research. Published investigations have characterized its receptor binding kinetics, peptidase-resistance profile attributed to the Pro-Gly-Pro extension, and interactions with multiple receptor systems in preclinical models.
Immune-Modulation Research in Preclinical Models
Because tuftsin is well-established as an endogenous immunomodulatory peptide, published research has examined Selank in immune-modulation contexts. Preclinical model studies have investigated interleukin expression profiles and innate immune system parameters in the context of tuftsin analog research.
Compound Comparison
Selank vs. Semax
Both are Russian-developed synthetic neuropeptide research compounds, both available at Sequence Labs — but they originate from distinct structural lineages and have been investigated in different receptor pathway contexts.
Selank — CAS 129954-34-3
- Synthetic analog of tuftsin (endogenous IgG-derived tetrapeptide)
- Heptapeptide: Thr-Lys-Pro-Arg-Pro-Gly-Pro · MW ~751 Da
- Pro-Gly-Pro extension for enhanced peptidase resistance in preclinical models
- Research focus: GABA-A pathway research, tuftsin receptor mechanism research, enkephalin system research
- Immune-modulation research lineage from parent tuftsin scaffold
- Available: 5mg, 10mg research vials
Semax — ACTH Analog
- Synthetic analog of ACTH(4–10) fragment (adrenocorticotropic hormone)
- Heptapeptide with Pro-Gly-Pro extension · Developed at Institute of Molecular Genetics, RAS
- Research focus: BDNF pathway research, ACTH receptor mechanism research, neurotrophin signaling
- MC4R and MC5R receptor research context in preclinical models
- Shared Russian Academy of Sciences developmental origin with Selank
- Available at Sequence Labs — see combined research page
Sequence Labs Supply
Selank Research Vials
Supplied as lyophilized powder. HPLC and mass spectrometry verified by Krause Analytical. Reviewed by Sabrina Runbeck, PA-C and Finnrick Pulse. For research use only.
- Selank lyophilized research vial
- HPLC + MS verified — Krause Analytical
- Certificate of Analysis included
- Reviewed: Sabrina Runbeck, PA-C
- Verified: Finnrick Pulse
- For research use only. Not for human use.
- Selank lyophilized research vial
- HPLC + MS verified — Krause Analytical
- Certificate of Analysis included
- Reviewed: Sabrina Runbeck, PA-C
- Verified: Finnrick Pulse
- For research use only. Not for human use.
- Independent third-party testing on every batch
- Krause Analytical — HPLC + mass spectrometry
- Sabrina Runbeck, PA-C — catalog review
- Finnrick Pulse — independent verification
- COA available in public library
Reconstitution Reference
Preparing a Selank Research Sample
Solvent introduction protocol — research use only
- Inspect the lyophilized research vial before use. Confirm the seal is intact, the powder is white to off-white, and the label matches the expected compound and lot number.
- Select an appropriate solvent for your research application. Bacteriostatic water (0.9% benzyl alcohol) is the commonly referenced solvent for neuropeptide research samples intended for extended storage. Sterile water for injection is suitable for immediate-use preparations.
- Introduce solvent slowly along the inner wall of the vial — do not direct the stream onto the lyophilized cake directly. Use a syringe appropriate for your research volume requirements.
- Allow the lyophilized powder to dissolve by gentle swirling. Do not shake vigorously. The resulting research solution should be clear and colorless to pale yellow.
- Store the reconstituted research sample at 2–8°C, protected from light. Use within the window consistent with your laboratory's standard operating procedures for peptide research samples.
- Label the vial with compound name, lot number, reconstitution date, solvent used, and final concentration calculated for your research volume.
Research use only. Not for human use. This reconstitution reference is provided for qualified research investigators working with Selank as a research compound only. No information here constitutes medical guidance, product claims, or instructions for human application. Sequence Labs LLC makes no representations regarding efficacy or safety for any non-research purpose.
Frequently Asked Questions
Selank Research FAQ
Ready to source Selank for your research?
Browse the full Sequence Labs research catalog, review the combined Semax / Selank research overview, or contact us directly with questions about your research requirements.
For research use only. Not for human use. All products supplied by Sequence Labs are for qualified research applications only and have not been evaluated by the FDA.