Compound Identity
What Is Semaglutide?
Semaglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist analog composed of 34 amino acids. It was developed by Novo Nordisk as a long-acting GLP-1 analog and received first FDA approval in 2017 under the brand name Ozempic for a specific clinical indication, followed by approval of Wegovy in 2021 under a separate indication.
The compound's molecular architecture is derived from native GLP-1(7–37), a naturally occurring incretin hormone. Semaglutide differs from native GLP-1 through two key structural modifications: a substitution at position 8 (replacing alanine with Aib, α-aminoisobutyric acid) to resist DPP-4 enzymatic cleavage, and the attachment of a C18 fatty diacid chain via a linker at lysine-26. This acylation enables albumin binding in plasma, dramatically extending the compound's half-life from the minutes seen with native GLP-1 to approximately one week.
Molecular specifications: Semaglutide is a 34-amino-acid synthetic peptide (C₁₈₇H₂₉₁N₄₅O₅₉, MW ≈ 4,113.58 Da) featuring a C18 fatty diacid moiety attached via an OEG-OEG-gamma-Glu-mini-PEG linker at Lys²⁶. CAS: 910463-68-2.
- Class: GLP-1 receptor agonist (GLP-1RA) — long-acting synthetic incretin analog
- Origin: Developed by Novo Nordisk; structurally derived from human GLP-1(7–37)
- Structural modification: Position-8 Aib substitution plus C18 fatty diacid chain for albumin binding
- Sequence origin: 94% sequence homology to human GLP-1; altered at 2 positions relative to natural sequence
- Research form: Supplied lyophilized (white to off-white powder) for research sample preparation
Published Research
Research Background
Semaglutide is among the most extensively studied GLP-1 receptor agonists in published scientific literature, with hundreds of peer-reviewed studies examining its receptor binding properties, incretin signaling mechanisms, and effects in various preclinical and in vitro models. The research interest spans multiple biological systems where GLP-1 receptors are expressed.
Sequence Labs Supply
Available Sizes, Testing & COA
Sequence Labs offers research-grade semaglutide in five lyophilized vial sizes. Every batch undergoes independent third-party testing through Krause Analytical in Austin, TX, with batch-specific COAs publicly accessible and verifiable via Finnrick Pulse.
| Size | Price | Form | COA | Stock |
|---|---|---|---|---|
| 5 mg | $43.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 10 mg | $70.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 15 mg | $97.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 20 mg | $128.99 | Lyophilized vial | ✓ Batch COA | In Stock |
| 30 mg | $148.99 | Lyophilized vial | ✓ Batch COA | In Stock |
Wholesale available. Licensed practitioners, compounding pharmacies, medical spas, and research institutions can apply for tiered B2B pricing — typically 18–32% below retail with no monthly commitment. View wholesale terms →
Research Preparation
Reconstitution Reference
The following describes standard laboratory procedures for preparing lyophilized research samples. This information is provided for qualified laboratory personnel. For research use only — not for human use.
- Inspect the vial. Confirm the vial seal is intact. Inspect the lyophilized research sample visually — it should appear as a white to off-white powder or cake. Verify the batch number against your COA from Krause Analytical.
- Select appropriate solvent. Bacteriostatic water (BAC water, 0.9% benzyl alcohol) is the most commonly used solvent for lyophilized peptide research samples. Use only sterile, research-grade solvent appropriate to your laboratory protocol.
- Introduce solvent to the vial. Using a sterile syringe, introduce the calculated volume of solvent slowly along the inner wall of the vial. Do not inject solvent directly onto the lyophilized cake.
- Allow to dissolve. Gently swirl — do not vortex or shake vigorously. Allow the lyophilized material to dissolve fully, which typically takes 1–3 minutes for semaglutide research preparations.
- Storage of reconstituted research sample. Store the reconstituted research preparation at 2–8°C (refrigerated) and use within the timeframe appropriate to your research protocol. Lyophilized (unreconstituted) vials should be stored at -20°C per COA instructions.
For research use only. All preparation and handling procedures must comply with applicable institutional, state, and federal regulations governing research compound handling. Sequence Labs provides this reference for laboratory informational purposes only.
Frequently Asked Questions
Semaglutide Research FAQ
Ready to Order?
Research-grade semaglutide, verified and in stock
Five sizes, batch COA from Krause Analytical, reviewed by reviewed by Sabrina Runbeck, PA-C. Order direct or apply for wholesale pricing.