Compound Profile
What Is Semax?
Semax is a synthetic heptapeptide classified as an ACTH analog neuropeptide. Its structure is based on the 4–7 fragment of adrenocorticotropic hormone (ACTH), extended with a Pro-Gly-Pro tripeptide tail. The full amino acid sequence — Met-Glu-His-Phe-Pro-Gly-Pro — was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.
The ACTH(4-7) core (Met-Glu-His-Phe) represents the biologically relevant fragment of ACTH studied for receptor binding characteristics in preclinical models. The Pro-Gly-Pro C-terminal extension was incorporated to enhance metabolic stability relative to the native ACTH(4-7) fragment, and is itself the subject of separate neuropeptide signaling research.
Semax is classified as a research compound and is supplied by Sequence Labs as a lyophilized research sample for in-vitro and preclinical research applications. For research use only. Not for human use.
Amino Acid Sequence
Met · Glu · His · Phe · Pro · Gly · Pro
[ ACTH(4-7) core: Met-Glu-His-Phe ] + [ Pro-Gly-Pro stability extension ]
Specifications
| Common Name | Semax |
| Classification | ACTH Analog Neuropeptide |
| Peptide Type | Heptapeptide (7 AA) |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Origin | ACTH(4-7) + Pro-Gly-Pro |
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | ~838 Da |
| CAS Number | 80714-61-0 |
| Developer | Inst. of Molecular Genetics, RAS |
| Research Classification | ACTH Analog / Neuropeptide |
| Available Sizes | 5mg · 10mg |
| Storage | Lyophilized, −20°C long-term |
| Purity | ≥99% (HPLC + MS verified) |
| Testing Lab | Krause Analytical |
| Use Classification | Research use only |
Preclinical Research Areas
Research Background
Published research has examined Semax across several neuropeptide signaling domains using preclinical animal models. The following areas represent documented research classifications.
BDNF / NGF Pathway Research in Preclinical Models
Published research has examined Semax in the context of BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) signaling in animal models. This BDNF pathway research is conducted under controlled preclinical laboratory conditions and characterizes Semax as a tool compound for studying neurotrophic factor interactions.
ACTH Receptor Mechanism Research
Published research has examined how the ACTH(4-7) core sequence of Semax interacts with melanocortin receptor subtypes. This ACTH receptor mechanism research uses Semax as a structural probe to investigate binding selectivity and downstream signaling in preclinical model systems.
Neuropeptide Signaling Pathway Research
As an ACTH analog neuropeptide, Semax has been used in published research to characterize neuropeptide signaling cascades. Research publications have examined how the heptapeptide structure — particularly the Pro-Gly-Pro extension — modulates signaling duration and pathway selectivity relative to the native ACTH(4-7) fragment.
Monoamine System Research in Animal Models
Published research has examined Semax in relation to dopamine and serotonin pathway dynamics in animal models. This monoamine system research uses Semax as a research tool to probe catecholamine and indoleamine neurotransmitter signaling under controlled laboratory conditions.
Neuroplasticity Pathway Research in Preclinical Models
Published preclinical research has examined Semax in neuroplasticity pathway studies using animal models. This neuroplasticity research investigates synaptic remodeling-related signaling mechanisms in controlled research settings and is distinct from any clinical or human-use application.
Published research index: Peer-reviewed publications examining Semax in ACTH analog and BDNF pathway contexts are indexed in the National Library of Medicine's PubMed database.
PubMed Index
Russian Neuropeptide Research Compounds
Semax vs. Selank
Both Semax and Selank are synthetic neuropeptide research compounds developed by Russian Academy of Sciences institutes. Published research has examined each through distinct mechanistic pathways in preclinical models.
This Compound
Semax
- Origin: Institute of Molecular Genetics, RAS
- Structure: ACTH(4-7) analog heptapeptide — Met-Glu-His-Phe-Pro-Gly-Pro
- Pathway research: ACTH receptor mechanism, BDNF/NGF pathway, monoamine system
- Core fragment: ACTH(4-7) with Pro-Gly-Pro stability extension
- MW: ~838 Da · CAS: 80714-61-0
- SL sizes: 5mg · 10mg
Related Compound
Selank
- Origin: Institute of Molecular Genetics, RAS
- Structure: Tuftsin (Thr-Lys-Pro-Arg) + Gly-Glu-Pro extension
- Pathway research: Tuftsin receptor research, GABAA modulatory pathway, anxiolytic signaling research
- Core fragment: Immunomodulatory tuftsin-derived tetrapeptide
- Research page: selank-research.html
- Combined page: semax-selank-research.html
Sequence Labs Supply
Semax Research Vials
HPLC and mass spectrometry tested by Krause Analytical. Certificate of Analysis on every batch. Reviewed by Sabrina Runbeck, PA-C. For research use only.
5mg Vial
~$40 / research vial
- 5mg lyophilized Semax research sample
- HPLC + MS tested — Krause Analytical
- Certificate of Analysis included
- ≥99% purity verified
- Reviewed: Sabrina Runbeck, PA-C
- Reviewed: Finnrick Pulse
- For research use only
10mg Vial
~$65 / research vial
- 10mg lyophilized Semax research sample
- HPLC + MS tested — Krause Analytical
- Certificate of Analysis included
- ≥99% purity verified
- Reviewed: Sabrina Runbeck, PA-C
- Reviewed: Finnrick Pulse
- Best value per mg research sample
- For research use only
Testing Lab
Krause Analytical
Test Methods
HPLC + Mass Spectrometry
Purity Standard
≥99% Verified
Catalog Review
Sabrina Runbeck, PA-C
Additional Review
Finnrick Pulse
Use Classification
Research Use Only
Research Sample Preparation
Reconstitution Reference
Standard research laboratory protocol for preparing lyophilized Semax research samples. For research use only. Not for human use.
1
Prepare Solvent
Bacteriostatic water (BW) is the standard solvent for Semax research sample preparation. Confirm sterility of all materials before beginning.
2
Introduce Solvent
Introduce the solvent slowly along the inner wall of the vial using a sterile syringe. Standard research reference: 1–2 mL bacteriostatic water per 5mg research vial.
3
Dissolve Without Agitation
Allow the lyophilized research sample to dissolve by gentle rotation. Do not shake or vortex. Semax is water-soluble and should dissolve completely without agitation.
4
Store Reconstituted Sample
Store reconstituted research sample at 2–8°C. Use within 30 days. Lyophilized vials may be stored at −20°C long-term prior to reconstitution.
Research use only. This reconstitution reference is provided for qualified laboratory researchers preparing Semax research samples for in-vitro or preclinical preclinical studies. This information is not instruction for human use. Sequence Labs supplies Semax exclusively as a research compound. Not for human use.
Common Questions
Semax Research FAQ
What is Semax?
Semax is a synthetic heptapeptide analog of ACTH(4-7) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Its full amino acid sequence is Met-Glu-His-Phe-Pro-Gly-Pro — a seven-residue peptide where the first four residues (Met-Glu-His-Phe) constitute the ACTH(4-7) core, and the final three (Pro-Gly-Pro) form a stability-enhancing C-terminal extension. CAS number: 80714-61-0. Molecular formula: C₃₇H₅₁N₉O₁₀S. MW: ~838 Da. Sequence Labs supplies Semax as a research compound for research use only.
What is the ACTH(4-7) connection?
Semax is structurally derived from residues 4 through 7 of adrenocorticotropic hormone (ACTH). The Met-Glu-His-Phe core sequence represents this ACTH(4-7) fragment. Published research has examined how this ACTH-derived core interacts with melanocortin receptor subtypes in preclinical models. The addition of the Pro-Gly-Pro extension distinguishes Semax from a simple ACTH(4-7) fragment and is itself the subject of separate neuropeptide stability research.
What BDNF pathway research involves Semax?
Published preclinical research has examined Semax in the context of BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) signaling pathways using animal models. This research is conducted under controlled laboratory conditions and uses Semax as a research tool compound for studying neurotrophic signaling. Published research examining Semax in relation to BDNF pathway activity is indexed on PubMed at pubmed.ncbi.nlm.nih.gov/?term=semax+ACTH+BDNF. Sequence Labs supplies Semax for research use only — not for human use.
What sizes does Sequence Labs offer?
Sequence Labs offers Semax in two research vial sizes: 5mg (approximately $40) and 10mg (approximately $65). Each vial contains lyophilized Semax research sample, tested by Krause Analytical using HPLC and mass spectrometry, with purity ≥99% verified. A Certificate of Analysis is available for every batch. Catalog has been reviewed by Sabrina Runbeck, PA-C and Finnrick Pulse. For research use only.
How is the research sample reconstituted?
For research sample preparation, bacteriostatic water is the standard solvent. Introduce the solvent slowly along the inner vial wall using a sterile syringe — do not agitate. A standard research reference point is 1–2 mL of bacteriostatic water per 5mg research vial. Store the reconstituted research sample at 2–8°C and use within 30 days. This reconstitution reference is for qualified laboratory researchers only. For research use only. Not for human use.
Is Semax for human use?
No. Semax from Sequence Labs is classified as a research compound and is supplied exclusively for in-vitro and preclinical research purposes by qualified laboratory researchers and licensed professionals. It is not approved by the U.S. Food and Drug Administration for human use, and is not intended to diagnose, treat, cure, or prevent any disease or condition in humans or animals. All products carry the classification: For research use only. Not for human use.
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Related Resources
Full Catalog
Products & Pricing
Browse Semax, Selank, and the complete Sequence Labs research compound catalog with current pricing and availability.
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Related Compound
Selank Research Compound
Tuftsin-derived heptapeptide from the Russian Academy of Sciences. GABA modulatory pathway and anxiolytic signaling research. 5mg and 10mg vials.
View Selank Page →
Compound Comparison
Semax & Selank Research
Side-by-side comparison of both Russian neuropeptide research compounds — ACTH/BDNF pathway versus tuftsin/GABA pathway research classifications.
View Comparison →
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